rs9341278

This is a intron variant variant in the UTY gene.

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Research that mentions this SNP (2)

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Forensic use of Y-chromosome DNA: a general overview
ReviewManfred Kayser et al.(2017)· Human Genetics

A comprehensive review of forensic applications of Y-chromosome DNA analysis, including Y-STR haplotyping for paternal lineage identification, paternity and kinship testing, familial searching, and bio-geographic ancestry inference. The paper illustrates these applications through the 14-year investigation of the 1999 Marianne Vaatstra murder case in the Netherlands, which was solved using Y-STR-based DNA dragnet and familial searching. The review discusses various Y-STR markers (9-27 loci), rapidly mutating Y-STRs for better discrimination, Y-SNP haplogroups for ancestry inference, and future directions in forensic Y-chromosome analysis.

Traits studied:Bio-geographic ancestry inferenceCrime scene investigationDisaster victim identificationFamilial searchingKinship analysisMissing person identificationPaternity testingY-chromosome paternal lineage identification
PubMedDOIMetascience Observatory
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Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
AssociationN=7,810Wang Z. et al.(2012)· Human Genetics

Two-phase association study examining Y chromosome haplogroups and prostate cancer risk in 3,995 cases and 3,815 controls (Stage I) with replication in 1,272 European and 1,686 Ashkenazi Jewish cases. The rare E1b1b1c haplogroup showed nominally significant association with prostate cancer overall (P=0.012, OR=0.51; 95% CI 0.30-0.87) in Stage I, with meta-analysis of stages I and II revealing a nominally significant association with prostate cancer risk (P=0.010, OR=0.77; 95% CI 0.62-0.94).

Traits studied:aggressive prostate cancernon-aggressive prostate cancerprostate cancer
PubMedDOIMetascience Observatory

About UTY

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2012]

View all UTY variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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